Resin Rundown: Meet Fmoc-PAL AM Resin – Your Go-To for Peptide Amides

In peptide chemistry, the C-terminus can make or break a molecule's bioactivity, solubility, and stability. If you're aiming for C-terminal amide peptides—a hallmark of many natural and therapeutic peptides—then Fmoc-PAL AM Resin is your best friend in the lab.

 What is Fmoc-PAL AM Resin?

Fmoc-PAL AM Resin is a polystyrene-based solid support functionalized with a 4-(4-aminomethyl-3,5-dimethoxyphenoxy)butyric acid (PAL) linker, pre-loaded with an Fmoc-protected amine. It’s specifically designed for Fmoc/tBu solid-phase peptide synthesis (SPPS) and delivers peptides with a C-terminal amide upon TFA cleavage.

• Fmoc: Fluorenylmethyloxycarbonyl protecting group for the N-terminus

• PAL Linker: Acid-labile linker for mild cleavage conditions

• AM = Amide: Indicates the peptide will have a C-terminal –NH₂ after cleavage

 Key Features

C-terminal Amide Formation – Perfect for peptides mimicking native sequences

Mild Cleavage – Linker is TFA-sensitive, preserving side chains with minimal degradation

High Purity – Produces clean, amide-terminated peptides

Compatible with Automation – Works well in automated SPPS systems

 Why Choose Fmoc-PAL AM Resin?

Many bioactive peptides (hormones, neuropeptides, etc.) exist naturally as amides at the C-terminus, which improves their stability, receptor binding, and in vivo half-life. Fmoc-PAL AM Resin lets you easily recreate that native amide structure during synthesis.

It’s especially favored for:

• Therapeutic peptide candidates

• Receptor-binding studies

• Peptides used in cell culture or in vivo assays

 Specifications at a Glance:

• Resin Type: Cross-linked polystyrene (typically 1% DVB)

• Linker: PAL (acid-labile, amide-yielding)

• Particle Size: ~100–200 mesh (75–150 µm)

• Loading: ~0.2–0.4 mmol/g

• Cleavage: TFA (trifluoroacetic acid) yields peptide amide

 Storage & Handling Tips

• Keep dry at 2–8 °C, away from moisture

• Swell in DMF or DCM before synthesis

• Minimize exposure to air and light for long-term storage

Final Thoughts

If your goal is to produce peptides with C-terminal amides that mirror their natural or therapeutic counterparts, Fmoc-PAL AM Resin is the gold standard. Clean cleavages, high purity, and predictable performance—what more could you ask for in a resin?