Fmoc-Phe-Wang Resin (100–200 Mesh): Preloaded Resin for C-Terminal Phenylalanine Peptides

Fmoc-Phe-Wang Resin is a preloaded polystyrene-based solid-phase resin designed for Fmoc/tBu solid-phase peptide synthesis (SPPS). It is functionalized with Fmoc-protected L-phenylalanine (Fmoc-Phe-OH) via an ester linkage to a Wang linker, anchored on a 100–200 mesh polystyrene-divinylbenzene (PS-DVB) matrix. Upon cleavage with trifluoroacetic acid (TFA), peptides synthesized on this resin bear a C-terminal free carboxylic acid (-COOH).

This resin is an ideal starting point for synthesizing C-terminal phenylalanine peptides, saving time by eliminating the first amino acid coupling step.

Specifications

• Matrix: Polystyrene cross-linked with ~1% DVB

• Linker: Wang (acid-labile ester linkage)

• Preloaded Amino Acid: Fmoc-L-Phenylalanine (Fmoc-Phe-OH)

• Functional Group: Esterified phenylalanine (–COO–Resin)

• Loading: Typically 0.6–1.1 mmol/g (varies by manufacturer)

• Particle Size: 100–200 mesh (approx. 75–150 µm)

• Compatible Chemistry: Fmoc-based SPPS

• Final Product: Peptide with C-terminal –COOH

Key Features

Preloaded with Fmoc-Phe: Ready-to-use for efficient SPPS

C-Terminal Acid: Ideal for biologically active peptides and pharmacological studies

Standard Mesh Size: Compatible with most synthesizers and manual protocols

Fmoc-Compatible: Fully compatible with standard Fmoc/tBu workflows

Stable & Reliable: Acid-labile Wang linker offers clean cleavage under TFA

Applications

• Peptide synthesis with C-terminal phenylalanine

• Biologically active peptides or hormone analogs

• Pharmacological studies and SAR exploration

• Library synthesis for screening or drug discovery

• Peptides requiring C-terminal free acid functionality

Cleavage & Deprotection

• Cleavage Cocktail: 95% TFA + 2.5% water + 2.5% TIS (or equivalent)

• Cleavage Time: 1–3 hours at room temperature

• Result: Peptide with a C-terminal –COOH, fully deprotected

Handling & Storage

• Store dry and protected from light and moisture

• Swell in DCM or DMF before use

• Compatible with manual or automated peptide synthesizers

• Stable under standard SPPS conditions (base washes, acid deprotection)

Comparison With Similar Resins

Conclusion

Fmoc-Phe-Wang Resin (100–200 mesh) offers a convenient and efficient solution for the synthesis of peptides with C-terminal phenylalanine and free carboxylic acid termini. Its ready-to-use format saves time while providing high loading capacity, excellent compatibility with standard SPPS protocols, and high-quality peptide products.

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