NovaSyn® TGR (TentaGel R) resin is a high-performance PEG-grafted polystyrene resin functionalized with a Rink amide linker, ideal for Fmoc/tBu SPPS. It is commonly used for the synthesis of C-terminal peptide amides, a feature found in many bioactive peptides and therapeutic candidates.

 Key Features:

• Resin Type: TentaGel (PEG-grafted polystyrene)

• Linker: Rink Amide (acid-labile, generates amide C-terminus)

• Functional Group: Primary amine (via Rink amide)

• Cleavage Condition: TFA (Trifluoroacetic acid), yields C-terminal amides

• Typical Loading: ~0.2–0.3 mmol/g (optimized for purity and yield)

• Particle Size: Generally 90–140 µm (depending on source)

• Swelling: Excellent swelling in polar solvents like DMF, DCM, NMP

 Advantages:

• Produces C-terminal amide peptides, mimicking natural peptides and increasing biological stability.

• Low substitution improves purity by minimizing aggregation during synthesis.

• PEGylation offers enhanced swelling and diffusion, increasing synthesis efficiency—especially for longer peptides.

• Compatible with automated and manual SPPS workflows.

Ideal For:

• Therapeutic peptide synthesis (many drugs end with amides)

• Long peptide chains or difficult sequences

• Applications where hydrophilicity and high solvation are beneficial

Storage:

• Store dry, at 2–8 °C, away from light and moisture.

• Keep sealed under inert atmosphere when possible.

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